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Proceedings Papers

Toward Defining the Role of Ca 2+ and MAP Kinases in Fluid-Induced Shear Regulation of Aggrecan in Chondrocytes

Clark T. Hung, Changbin B. Wang, Ross Henshaw, Wilmot B. Valhmu, Mary B. Goldring

Proc. ASME. IMECE98, Advances in Bioengineering, 59-60, November 15–20, 1998

Paper No: IMECE1998-0030

DOI: https://doi.org/10.1115/IMECE1998-0030

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Topics: Chondrocytes, Fluids, Shear (Mechanics), Proteins

Proceedings Papers

Is Articular Cartilage Orthotropic in Compression?

Michael A. Soltz, Robert L. Mauck, Clark T. Hung, Gerard A. Ateshian

Proc. ASME. IMECE99, Advances in Bioengineering, 209-210, November 14–19, 1999

Paper No: IMECE1999-0451

DOI: https://doi.org/10.1115/IMECE1999-0451

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Topics: Cartilage, Compression, Tension, Anisotropy, Biological tissues, Strips

Proceedings Papers

Chondrocyte Translocation and Orientation to Applied DC Electric Fields

Robert L. Mauck, Pen-hsiu G. Chao, Beth Gilbert, Wilmot B. Valhmu, Clark T. Hung

Proc. ASME. IMECE99, Advances in Bioengineering, 117-118, November 14–19, 1999

Paper No: IMECE1999-0405

DOI: https://doi.org/10.1115/IMECE1999-0405

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Topics: Chondrocytes, Electric fields, Cartilage, Bioengineering, Biological tissues, Bone, Cornea, Fibroblasts, Maintenance, Shapes

Proceedings Papers

Time-Varying Effect of Ascorbate on the Compressive Modulus and Gag Content of Chondrocyte-Seeded Agarose Cultures

Robert L. Mauck, Michael A. Soltz, Beth Gilbert, Gerard A. Ateshian, Clark T. Hung, Frank J. Raia, Wilmot B. Valhmu

Proc. ASME. IMECE99, Advances in Bioengineering, 105-106, November 14–19, 1999

Paper No: IMECE1999-0399

DOI: https://doi.org/10.1115/IMECE1999-0399

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Topics: Agar, Chondrocytes, Disks, Cartilage, Mechanical properties, Assaying, Biological tissues

Proceedings Papers

Direct Hydraulic Permeability Measurements of Agarose Hydrogels Used as Cell Scaffolds

Michael A. Soltz, Anna Stankiewicz, Gerard Ateshian, Robert L. Mauck, Clark T. Hung

Proc. ASME. IMECE99, Advances in Bioengineering, 229-230, November 14–19, 1999

Paper No: IMECE1999-0461

DOI: https://doi.org/10.1115/IMECE1999-0461

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Topics: Agar, Hydrogels, Permeability, Fluids, Chondrocytes, Cartilage, Fluid dynamics, Bearings, Compacting, Ions

Proceedings Papers

The Strain-Softening of Bovine Articular Cartilage Under Infinitesimal Deformation in Unconfined Compression

Christopher C.-B. Wang, Nadeen O. Chahine, Terri-Ann N. Kelly, W. Michael Lai, Clark T. Hung, Gerard A. Ateshian

Proc. ASME. IMECE2001, Advances in Bioengineering, 123-124, November 11–16, 2001

Paper No: IMECE2001/BED-23061

DOI: https://doi.org/10.1115/IMECE2001/BED-23061

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Topics: Cartilage, Compression, Deformation, Biological tissues, Osmosis, Buckling, Constitutive equations, Elasticity, Equilibrium (Physics), Fibers

Proceedings Papers

Mechanical Loading Modulates Gene Expression in Chondrocyte-Seeded Agarose Hydrogels

Sansan S. Lo, Robert L. Mauck, Sara L. Seyhan, Glyn D. Palmer, Van C. Mow, Clark T. Hung

Proc. ASME. IMECE2001, Advances in Bioengineering, 291-292, November 11–16, 2001

Paper No: IMECE2001/BED-23145

DOI: https://doi.org/10.1115/IMECE2001/BED-23145

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Topics: Agar, Chondrocytes, Hydrogels, Cartilage, Stress, Biological tissues, Bearings, Bioreactors, Compression, Dynamic testing (Materials)

Proceedings Papers

Temporal Development of Material Properties in Free Swelling Chondrocyte-Seeded Agarose Constructs

Terri-Ann N. Kelly, Christopher C.-B. Wang, Nadeen O. Chahine, Gerard A. Ateshian, Clark T. Hung

Proc. ASME. IMECE2001, Advances in Bioengineering, 289-290, November 11–16, 2001

Paper No: IMECE2001/BED-23144

DOI: https://doi.org/10.1115/IMECE2001/BED-23144

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Topics: Agar, Chondrocytes, Materials properties, Biological tissues, Biomechanics, Cartilage, Displacement, Hydrogels, Microscopy, Poisson ratio

Proceedings Papers

Dynamic Hydrostatic Pressurization Increases Matrix Gene Expression by Chondrocytes in 3D Culture

Robert L. Mauck, Michael A. Soltz, Gerard A. Ateshian, Clark T. Hung

Proc. ASME. IMECE2001, Advances in Bioengineering, 295-296, November 11–16, 2001

Paper No: IMECE2001/BED-23147

DOI: https://doi.org/10.1115/IMECE2001/BED-23147

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Topics: Chondrocytes, Hydrostatics, Cartilage, Hydrostatic pressure, Pressure, Stress, Bearings, Bone, Deformation, Hydrogels

Proceedings Papers

A Novel Device for Direct Permeation Measurements of Hydrogels and Soft Hydrated Tissues

Nelly A. Andarawis, Sara L. Seyhan, Robert L. Mauck, Michael A. Soltz, Gerard A. Ateshian, Clark T. Hung

Proc. ASME. IMECE2001, Advances in Bioengineering, 299-300, November 11–16, 2001

Paper No: IMECE2001/BED-23149

DOI: https://doi.org/10.1115/IMECE2001/BED-23149

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Topics: Biological tissues, Hydrogels, Permeability, Cartilage, Deformation, Fluids, Agar, Bearings, Design, Lubrication

Proceedings Papers

Dynamic Compression Stimulates the Development of Equilibrium Aggregate Modulus in Tissue Engineered Cartilage Constructs

Robert L. Mauck, Glyn D. Palmer, Christopher C.-B. Wang, Michael A. Soltz, Wilmot B. Valhmu, Gerard A. Ateshian, Clark T. Hung

Proc. ASME. IMECE2000, Advances in Bioengineering, 67-68, November 5–10, 2000

Paper No: IMECE2000-2518

DOI: https://doi.org/10.1115/IMECE2000-2518

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Topics: Biological tissues, Cartilage, Compression, Equilibrium (Physics), Agar, Bearings, Functional materials, Physiology, Stress, Tissue engineering

Proceedings Papers

Cathodal Migration of Chondrocytes to Applied DC Electric Fields: Effects of Neomycin

Pen-hsiu G. Chao, Wendy Liu, Rani Roy, Robert L. Mauck, Clark T. Hung

Proc. ASME. IMECE2000, Advances in Bioengineering, 65-66, November 5–10, 2000

Paper No: IMECE2000-2517

DOI: https://doi.org/10.1115/IMECE2000-2517

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Topics: Chondrocytes, Electric fields, Temperature, Cartilage, Maintenance, Physiology

Journal Articles

Direct Osmotic Pressure Measurements in Articular Cartilage Demonstrate Nonideal and Concentration-Dependent Phenomena

Brandon K. Zimmerman, Robert J. Nims, Alex Chen, Clark T. Hung, Gerard A. Ateshian

J Biomech Eng. April 2021, 143(4): 041007.

Paper No: BIO-20-1368

DOI: https://doi.org/10.1115/1.4049158

Published Online: December 16, 2020

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Topics: Cartilage, Osmosis, Pressure, Biological tissues, Stress

Proceedings Papers

Finite Element Modeling of Osmotic Swelling in Tissue-Engineered Cartilage

Liming Bian, Terri Ann N. Kelly, Eric G. Lima, Gerard A. Ateshian, Clark T. Hung

Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 269-270, June 25–29, 2008

Paper No: SBC2008-192368

DOI: https://doi.org/10.1115/SBC2008-192368

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Topics: Biological tissues, Cartilage, Finite element analysis, Modeling, Bearings, Chondrocytes, Cracking (Materials), Fracture (Process), Hydrogels, Maintenance

Proceedings Papers

Genipin Protects Engineered Cartilage Against IL-1alpha Induced Degradation

Andrea R. Tan, Eric G. Lima, Kacey G. Marra, Clark T. Hung

Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 621-622, June 25–29, 2008

Paper No: SBC2008-193070

DOI: https://doi.org/10.1115/SBC2008-193070

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Topics: Cartilage, Biological tissues, Osteoarthritis, Surgery, Tissue engineering

Proceedings Papers

The Response of Tissue Engineered Cartilage to the Temporal Application of Transforming and Insulin-Like Growth Factors

Christopher J. O’Conor, Kenneth W. Ng, Lindsay E. Kugler, Gerard A. Ateshian, Clark T. Hung

Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 1023-1024, June 20–24, 2007

Paper No: SBC2007-176523

DOI: https://doi.org/10.1115/SBC2007-176523

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Topics: Biological tissues, Cartilage, Tissue engineering, Agar, Biocompatibility, Chondrocytes, Mechanical properties

Proceedings Papers

Scaffold Properties Play a Critical Role in the Retention of Synthesized Glycosaminoglycans in Tissue Engineered Cartilage

Lindsay E. Kugler, Kenneth W. Ng, Christopher J. O’Conor, Gerard A. Ateshian, Clark T. Hung

Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 1031-1032, June 20–24, 2007

Paper No: SBC2007-176558

DOI: https://doi.org/10.1115/SBC2007-176558

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Topics: Biological tissues, Cartilage, Agar, Tissue engineering, Chondrocytes, Diffusion (Physics), Explosives, Maintenance, Physiology, Testing

Proceedings Papers

The Role of Microtubule Organization in Chondrocyte Response to Osmotic Loading

Elizabeth S. Oswald, Pen-hsiu Grace Chao, J. Chloe Bulinski, Gerard A. Ateshian, Clark T. Hung

Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 277-278, June 20–24, 2007

Paper No: SBC2007-176634

DOI: https://doi.org/10.1115/SBC2007-176634

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Topics: Chondrocytes, Cartilage, Physiology, Signals

Proceedings Papers

Influence of Nutrient Channels on Development of Engineered Cartilage Properties

Liming Bian, Kenneth W. Ng, Eric G. Lima, Gerard A. Ateshian, Clark T. Hung

Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 1055-1056, June 20–24, 2007

Paper No: SBC2007-176234

DOI: https://doi.org/10.1115/SBC2007-176234

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Topics: Agar, Cartilage, Chondrocytes, Diffusion (Physics), Dimensions, Materials properties, Mechanical properties

Proceedings Papers

Fickian Behavior and Concentration-Dependence of the Diffusion of Dextran in Agarose

Michael B. Albro, Vikram Rajan, Clark T. Hung, Gerard A. Ateshian

Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 1061-1062, June 20–24, 2007

Paper No: SBC2007-176646

DOI: https://doi.org/10.1115/SBC2007-176646

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Topics: Agar, Diffusion (Physics), Biological tissues, Cartilage, Chondrocytes, Dynamic testing (Materials), Fluorescence, Macromolecules, Mechanical properties, Soft tissues

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Journal citation

NARROW

Toward Defining the Role of Ca 2+ and MAP Kinases in Fluid-Induced Shear Regulation of Aggrecan in Chondrocytes

Is Articular Cartilage Orthotropic in Compression?

Chondrocyte Translocation and Orientation to Applied DC Electric Fields

Time-Varying Effect of Ascorbate on the Compressive Modulus and Gag Content of Chondrocyte-Seeded Agarose Cultures

Direct Hydraulic Permeability Measurements of Agarose Hydrogels Used as Cell Scaffolds

The Strain-Softening of Bovine Articular Cartilage Under Infinitesimal Deformation in Unconfined Compression

Mechanical Loading Modulates Gene Expression in Chondrocyte-Seeded Agarose Hydrogels

Temporal Development of Material Properties in Free Swelling Chondrocyte-Seeded Agarose Constructs

Dynamic Hydrostatic Pressurization Increases Matrix Gene Expression by Chondrocytes in 3D Culture

A Novel Device for Direct Permeation Measurements of Hydrogels and Soft Hydrated Tissues

Dynamic Compression Stimulates the Development of Equilibrium Aggregate Modulus in Tissue Engineered Cartilage Constructs

Cathodal Migration of Chondrocytes to Applied DC Electric Fields: Effects of Neomycin

Direct Osmotic Pressure Measurements in Articular Cartilage Demonstrate Nonideal and Concentration-Dependent Phenomena

Finite Element Modeling of Osmotic Swelling in Tissue-Engineered Cartilage

Genipin Protects Engineered Cartilage Against IL-1alpha Induced Degradation

The Response of Tissue Engineered Cartilage to the Temporal Application of Transforming and Insulin-Like Growth Factors

Scaffold Properties Play a Critical Role in the Retention of Synthesized Glycosaminoglycans in Tissue Engineered Cartilage

The Role of Microtubule Organization in Chondrocyte Response to Osmotic Loading

Influence of Nutrient Channels on Development of Engineered Cartilage Properties

Fickian Behavior and Concentration-Dependence of the Diffusion of Dextran in Agarose

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