Two different preparations of biocompatible magnetic nanoparticles (MNPs), both (MnFe2O4 and Mn0.91Zn0.09Fe2O4) coated with methoxy polyethylene glycol aldehyde (m-PEG-CHO) were prepared through coprecipitation method. The prepared powder was reanalyzed for material structure with an X-ray diffractometer (XRD) and for particle size using a transition electron microscope (TEM). Magnetic saturation (MS) and coercivity (HC) of the formed particles were examined by a vibrating sample magnetometer (VSM). Surface structure of the samples was characterized by Fourier transform infrared spectroscopy (FTIR). Biocompatible ferrofluids were intravenously injected into four rabbits. Then the magnetic resonance (MR) images of brain were obtained by magnetic resonance imaging (MRI) experiments before and after intravenous injection of ferrofluids. The MNPs demonstrate super paramagnetic behavior with a spinel structure measuring 30–40 nm in size. Doping of these magnetite nanoparticles with zinc resulted in decreases in crystallite size from 24.23 nm to 21.15 nm, the lattice parameter from 8.45 Å to 8.43 Å and the coercivity from 41.20 Oe to 13.07 Oe. On the other hand, saturation magnetization increased from 50.12 emu/g to 57.36 emu/g following zinc doping. Image exposure analysis revealed that the reduction of MR signal intensity for zinc-doped magnetite nanoparticles was more than nondoped nanoparticles (shorter T2 relaxation time) thereby making the images darker.
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November 2014
Research-Article
Synthesis of Zn-Doped Manganese Ferrite Nanoparticles Via Coprecipitation Method for Magnetic Resonance Imaging Contrast Agent
Firooz Salehpour,
Firooz Salehpour
Professor
Department of Neurosurgery,
e-mail: firoozsalehpour@hotmail.com
Department of Neurosurgery,
Tabriz University of Medical Sciences
,Tabriz
, Iran
e-mail: firoozsalehpour@hotmail.com
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Ainaz Khorramdin,
Ainaz Khorramdin
Department of Material Sciences
and Engineering,
e-mail: a.khorramdin@sutech.ac.ir
and Engineering,
Shiraz University of Technology
,Shiraz
, Iran
e-mail: a.khorramdin@sutech.ac.ir
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Hooman Shokrollahi,
Hooman Shokrollahi
Assistant Professor
Department of Material Sciences
and Engineering,
e-mail: shokrollahi@sutech.ac.ir
Department of Material Sciences
and Engineering,
Shiraz University of Technology
,Shiraz
, Iran
e-mail: shokrollahi@sutech.ac.ir
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Arastoo Pezeshki,
Arastoo Pezeshki
Department of Material Sciences
and Engineering,
e-mail: Draraspz@yahoo.com
and Engineering,
Shiraz University of Technology
,Shiraz
, Iran
e-mail: Draraspz@yahoo.com
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Farhad Mirzaei,
Farhad Mirzaei
Department of Neurosurgery,
Tabriz University of Medical Sciences
,Tabriz
, Iran
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Nader D. Nader
Nader D. Nader
1
Professor
Department of Anesthesiology,
e-mail: nnader@buffalo.edu
Department of Anesthesiology,
University at Buffalo
252 Farber Hall
,South Campus
,Buffalo, NY 14214
e-mail: nnader@buffalo.edu
1Corresponding author.
Search for other works by this author on:
Firooz Salehpour
Professor
Department of Neurosurgery,
e-mail: firoozsalehpour@hotmail.com
Department of Neurosurgery,
Tabriz University of Medical Sciences
,Tabriz
, Iran
e-mail: firoozsalehpour@hotmail.com
Ainaz Khorramdin
Department of Material Sciences
and Engineering,
e-mail: a.khorramdin@sutech.ac.ir
and Engineering,
Shiraz University of Technology
,Shiraz
, Iran
e-mail: a.khorramdin@sutech.ac.ir
Hooman Shokrollahi
Assistant Professor
Department of Material Sciences
and Engineering,
e-mail: shokrollahi@sutech.ac.ir
Department of Material Sciences
and Engineering,
Shiraz University of Technology
,Shiraz
, Iran
e-mail: shokrollahi@sutech.ac.ir
Arastoo Pezeshki
Department of Material Sciences
and Engineering,
e-mail: Draraspz@yahoo.com
and Engineering,
Shiraz University of Technology
,Shiraz
, Iran
e-mail: Draraspz@yahoo.com
Farhad Mirzaei
Department of Neurosurgery,
Tabriz University of Medical Sciences
,Tabriz
, Iran
Nader D. Nader
Professor
Department of Anesthesiology,
e-mail: nnader@buffalo.edu
Department of Anesthesiology,
University at Buffalo
252 Farber Hall
,South Campus
,Buffalo, NY 14214
e-mail: nnader@buffalo.edu
1Corresponding author.
Manuscript received August 1, 2014; final manuscript received February 13, 2015; published online March 11, 2015. Assoc. Editor: Roger Narayan.
J. Nanotechnol. Eng. Med. Nov 2014, 5(4): 041002 (6 pages)
Published Online: November 1, 2014
Article history
Received:
August 1, 2014
Revision Received:
February 13, 2015
Online:
March 11, 2015
Citation
Salehpour, F., Khorramdin, A., Shokrollahi, H., Pezeshki, A., Mirzaei, F., and Nader, N. D. (November 1, 2014). "Synthesis of Zn-Doped Manganese Ferrite Nanoparticles Via Coprecipitation Method for Magnetic Resonance Imaging Contrast Agent." ASME. J. Nanotechnol. Eng. Med. November 2014; 5(4): 041002. https://doi.org/10.1115/1.4029855
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