Ocular drug delivery is a complex and challenging process and understanding the transport characteristics of drug-loaded particles is very important for designing safe and effective ocular drug delivery devices. In this paper, we investigated the effect of the microchannel configuration of the microdevice, the size of drug-loaded nanoparticles (NPs), and the pressure gradient of fluid flow in determining the maximum number of NPs within a certain outlet region and transportation time of drug particles. We employed a hybrid computational approach that combines the lattice Boltzmann model for fluids with the Brownian dynamics model for NPs transport. This hybrid approach allows to capture the interactions among the fluids, NPs, and barriers of microchannels. Our results showed that increasing the pressure gradient of fluid flow in a specific type of microchannel configuration (tournament configuration) effectively decreased the maximum number of NPs within a certain outlet region as well as transportation time of the drug loaded NPs. These results have important implications for the design of ocular drug delivery devices. These findings may be particularly helpful in developing design and transport optimization guidelines related to creating novel microchannel configurations for ocular drug delivery devices.
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August 2014
Research-Article
Simulation of Drug-Loaded Nanoparticles Transport Through Drug Delivery Microchannels
Yongting Ma,
Yongting Ma
Department of Mechanical
and Nuclear Engineering,
and Nuclear Engineering,
Virginia Commonwealth University
,Richmond, VA 23284
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Ramana M. Pidaparti
Ramana M. Pidaparti
1
1Corresponding author.
Search for other works by this author on:
Yongting Ma
Department of Mechanical
and Nuclear Engineering,
and Nuclear Engineering,
Virginia Commonwealth University
,Richmond, VA 23284
Ramana M. Pidaparti
1Corresponding author.
Manuscript received October 22, 2013; final manuscript received September 30, 2014; published online November 11, 2014. Assoc. Editor: Malisa Sarntinoranont.
J. Nanotechnol. Eng. Med. Aug 2014, 5(3): 031002 (7 pages)
Published Online: August 1, 2014
Article history
Received:
October 22, 2013
Revision Received:
September 30, 2014
Online:
November 11, 2014
Citation
Ma, Y., and Pidaparti, R. M. (August 1, 2014). "Simulation of Drug-Loaded Nanoparticles Transport Through Drug Delivery Microchannels." ASME. J. Nanotechnol. Eng. Med. August 2014; 5(3): 031002. https://doi.org/10.1115/1.4028732
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