To develop a novel endovascular chemotherapy filter (CF) able to remove excess drug from the blood during intra-arterial chemotherapy delivery (IAC), thus preventing systemic toxicities and thereby enabling higher dose IAC. A flow circuit containing 2.5 mL of ion-exchange resin was constructed. Phosphate-buffered saline (PBS) containing 50 mg doxorubicin (Dox) was placed in the flow model with the hypothesis that doxorubicin would bind rapidly to resin. To simulate IAC, 50 mg of doxorubicin was infused over 10 min into the flow model containing resin. Similar testing was repeated with porcine serum. Doxorubicin concentrations were measured over 60 min and compared to controls (without resin). Single-pass experiments were also performed. Based on these experiments, an 18F CF was constructed with resin in its tip. In a pilot porcine study, the device was deployed under fluoroscopy. A control hepatic doxorubicin IAC model (no CF placed) was developed in another animal. A second CF device was created with a resin membrane and tested in the infrarenal inferior vena cava (IVC) of a swine. In the PBS model, resin bound 76% of doxorubicin in 10 min, and 92% in 30 min (P < 0.001). During IAC simulation, 64% of doxorubicin bound in 10 min and 96% in 60 min (P < 0.001). On average, 51% of doxorubicin concentration was reduced during each pass in single pass studies. In porcine serum, 52% of doxorubicin bound in 10 min, and 80% in 30 min (P < 0.05). CF device placement and administration of IAC were successful in three animals. No clot was present on the resin within the CF following the in vivo study. The infrarenal IVC swine study demonstrated promising results with up to 85% reduction in peak concentration by the CF device. An endovascular CF device was developed and shown feasible in vitro. An in vivo model was established with promising results supporting high-capacity rapid doxorubicin filtration from the blood that can be further evaluated in future studies.
Skip Nav Destination
645 Woodstock Road,
645 Woodstock Road,
Article navigation
December 2014
Research-Article
Development and Validation of Endovascular Chemotherapy Filter Device for Removing High-Dose Doxorubicin: Preclinical Study
Anand S. Patel,
Anand S. Patel
1
Department of Radiology and Biomedical Imaging,
185 Berry Street, Suite 350,
e-mail: anand.patel@ucsf.edu
University of California San Francisco
,185 Berry Street, Suite 350,
San Francisco, CA 94107-5705
e-mail: anand.patel@ucsf.edu
1Corresponding author.
Search for other works by this author on:
Maythem Saeed,
Maythem Saeed
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Search for other works by this author on:
Erin J. Yee,
Erin J. Yee
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Search for other works by this author on:
Jeffrey Yang,
Jeffrey Yang
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Search for other works by this author on:
Gregory J. Lam,
Gregory J. Lam
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Search for other works by this author on:
Aaron D. Losey,
Aaron D. Losey
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Search for other works by this author on:
Prasheel V. Lillaney,
Prasheel V. Lillaney
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Search for other works by this author on:
Bradford Thorne,
Bradford Thorne
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Search for other works by this author on:
Albert K. Chin,
645 Woodstock Road,
Albert K. Chin
ChemoFilter, Inc.
,645 Woodstock Road,
Hillsborough, CA 94010
Search for other works by this author on:
Sheena Malik,
645 Woodstock Road,
Sheena Malik
ChemoFilter, Inc.
,645 Woodstock Road,
Hillsborough, CA 94010
Search for other works by this author on:
Mark W. Wilson,
Mark W. Wilson
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Search for other works by this author on:
Xi C. Chen,
Xi C. Chen
Materials Sciences Division,
Lawrence Berkeley National Laboratory
,Berkeley, CA 94720
Search for other works by this author on:
Nitash P. Balsara,
Nitash P. Balsara
Materials Sciences Division,
Lawrence Berkeley National Laboratory
,Berkeley, CA 94720
;Environmental Energy Technologies Division,
Lawrence Berkeley National Laboratory
,Berkeley, CA 94720
;Department of Chemical and
Biomolecular Engineering,
Biomolecular Engineering,
University of California
,Berkeley, CA 94720
Search for other works by this author on:
Steven W. Hetts
Steven W. Hetts
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Search for other works by this author on:
Anand S. Patel
Department of Radiology and Biomedical Imaging,
185 Berry Street, Suite 350,
e-mail: anand.patel@ucsf.edu
University of California San Francisco
,185 Berry Street, Suite 350,
San Francisco, CA 94107-5705
e-mail: anand.patel@ucsf.edu
Maythem Saeed
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Erin J. Yee
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Jeffrey Yang
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Gregory J. Lam
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Aaron D. Losey
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Prasheel V. Lillaney
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Bradford Thorne
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Albert K. Chin
ChemoFilter, Inc.
,645 Woodstock Road,
Hillsborough, CA 94010
Sheena Malik
ChemoFilter, Inc.
,645 Woodstock Road,
Hillsborough, CA 94010
Mark W. Wilson
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
Xi C. Chen
Materials Sciences Division,
Lawrence Berkeley National Laboratory
,Berkeley, CA 94720
Nitash P. Balsara
Materials Sciences Division,
Lawrence Berkeley National Laboratory
,Berkeley, CA 94720
;Environmental Energy Technologies Division,
Lawrence Berkeley National Laboratory
,Berkeley, CA 94720
;Department of Chemical and
Biomolecular Engineering,
Biomolecular Engineering,
University of California
,Berkeley, CA 94720
Steven W. Hetts
Department of Radiology and Biomedical Imaging,
University of California San Francisco
,San Francisco, CA 94107
1Corresponding author.
Manuscript received November 12, 2013; final manuscript received April 3, 2014; published online xx xx, xxxx. Assoc. Editor: Rupak K. Banerjee.
J. Med. Devices. Dec 2014, 8(4): 041008 (8 pages)
Published Online: August 19, 2014
Article history
Received:
November 12, 2013
Revision Received:
April 3, 2014
Citation
Patel, A. S., Saeed, M., Yee, E. J., Yang, J., Lam, G. J., Losey, A. D., Lillaney, P. V., Thorne, B., Chin, A. K., Malik, S., Wilson, M. W., Chen, X. C., Balsara, N. P., and Hetts, S. W. (August 19, 2014). "Development and Validation of Endovascular Chemotherapy Filter Device for Removing High-Dose Doxorubicin: Preclinical Study." ASME. J. Med. Devices. December 2014; 8(4): 041008. https://doi.org/10.1115/1.4027444
Download citation file:
Get Email Alerts
Cited By
Comanipulation Robotic Platform for Spine Surgery With Exteroceptive Visual Coupling: Development and Experimentation
J. Med. Devices (December 2022)
Preclinical Evaluation of a Task-Shifting Contraceptive Implant Insertion Device for Use in Low- and Middle-Income Countries
J. Med. Devices (December 2022)
Related Articles
Pre-Clinical Evaluation of Direct Current Ablation for the Treatment of Benign Prostatic Hyperplasia
J. Med. Devices (June,2009)
Thrombogenicity Testing of Medical Devices in a Minimally Heparinized Ovine Blood Loop
J. Med. Devices (June,2017)
A High-Throughput In Vitro Model Illustrating Potential Microbiological Interactions During Treatment of Pseudomonas Aeruginosa Biofilm Associated Infections
J. Med. Devices (June,2008)
Multiscale Computational Fluid Dynamics Modeling for Personalized Liver Cancer Radioembolization Dosimetry
J Biomech Eng (January,2021)
Related Proceedings Papers
Related Chapters
Bioinformatic Analysis of the Malay Peninsular Macaca Fascicularis Based on Cytochrome C Oxidase I Sequences
International Conference on Computer Research and Development, 5th (ICCRD 2013)
Experimental Studies
Nanoparticles and Brain Tumor Treatment
Conclusions
Nanoparticles and Brain Tumor Treatment