Cosimulation is widely used as a powerful tool for performance evaluation of systems design. This approach presents advantages over traditional design methodologies for saving money and time in the development process and the possibility of evaluating rapidly design alternatives by using virtual prototypes. This article presents an adams/matlab cosimulation for the dynamics and control of a Single-Wheel pendulum ROBot (SWROB) with inertial locomotion actuation to characterize design solutions by means of validation of analytical results. The obtained results by the proposed cosimulation show a significant performance based on the analytical and programming efforts in characterizing and simulating the designed system model. Moreover, open-loop experimental results are presented to validate both the analytical model and the virtual prototype.