Abstract
In the midst of a huge demand for high-precision miniaturized medical implants made up of potential biomaterials, the biomedical Ti-6Al-4V alloy meets the uncompromising standards for longevity, biocompatibility, and sterilizability required to interact with living cells in medical settings. This research tailored the existing capabilities of a traditional micro-electric discharge machining (µ-EDM) setup by adding 0, 2, 4, 6, 8, and 10 g/l bioactive zinc powder particle concentrations (PPCs) to the dielectric. A copper and brass micro-tool electrode (C-µ-TE and B-µ-TE) was employed in association with each PPC. Experiments were executed using the one-variable-at-a-time (OVAT) approach. Machining time and dimensional deviation were chosen as the response variables of Zn powder mixed-micro-EDM (Zn-PM-µ-EDM). According to the analytical findings, the combination of C-µ-TE and 6 g/l Zn PPC achieved 23.52%, 3.29%, and 17.96% lesser machining time, dimensional deviation, and recast layer thickness, respectively, compared to the B-µ-TE. The detailed study of this surface endorsed a significant modification in terms of improved recast layer thickness (26.44 µm), topography (Ra = 743.65 nm), and wettability (contact angle < 90 deg), suggesting its dental application. In addition, the observation of ZnO and TiO in X-ray diffraction and appealing in vitro cytocompatibility encourage the subsequent biological and therapeutic studies to validate the anticipated antiviral activity of the modified Ti-6Al-4V alloy surface against coronavirus (COVID-19).
Issue Section:
Research Papers
Keywords:
powder mixed-µ-EDM, biomedical Ti-6Al-4V,
µ-tool electrode,
zinc powder,
machining time,
dimensional deviation,
advanced materials and processing,
biomedical manufacturing,
machining processes,
micro- and nano-machining and processing,
nontraditional manufacturing processes,
powder processing
References
1.
Mordor Intelligence
, 2021
, “Biomaterials Market—Growth, Trends, COVID-19 Impact, and Forecasts (2021–2026)
,” https://www.mordorintelligence.com/industry-reports/biomaterials-market, Accessed May 11, 2021.2.
Food and Drug Administration (FDA)
, 2019
, “Implants and Prosthetics
,” https://www.fda.gov/medical-devices/products-and-medical-procedures/implants-and-prosthetics, Accessed May 23, 2021.3.
Zhang
, L. C.
, and Chen
, L. Y.
, 2019
, “A Review on Biomedical Titanium Alloys: Recent Progress and Prospect
,” Adv. Eng. Mater.
, 21
(4
), pp. 1
–29
.4.
Fukuda
, A.
, Takemoto
, M.
, Saito
, T.
, Fujibayashi
, S.
, Neo
, M.
, Yamaguchi
, S.
, Kizuki
, T.
, Matsushita
, T.
, Niinomi
, M.
, Kokubo
, T.
, and Nakamura
, T.
, 2011
, “Bone Bonding Bioactivity of Ti Metal and Ti–Zr–Nb–Ta Alloys With Ca Ions Incorporated on Their Surfaces by Simple Chemical and Heat Treatments
,” Acta Biomater.
, 7
(3
), pp. 1379
–1386
. 5.
Oshida
, Y.
, 2013
, “Surface Modifications,” Bioscience and Bioengineering of Titanium Materials
, Elsevier
, pp. 341
–456
.6.
Xue
, T.
, Attarilar
, S.
, Liu
, S.
, Liu
, J.
, Song
, X.
, Li
, L.
, Zhao
, B.
, and Tang
, Y.
, 2020
, “Surface Modification Techniques of Titanium and Its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review
,” Front. Bioeng. Biotechnol.
, 8
, p. 1261
.7.
Cooper
, B. G.
, Bordeianu
, C.
, Nazarian
, A.
, Snyder
, B. D.
, and Grinstaff
, M. W.
, 2018
, “Active Agents, Biomaterials, and Technologies to Improve Biolubrication and Strengthen Soft Tissues
,” Biomaterials
, 181
, pp. 210
–226
. 8.
Davis
, R.
, Singh
, A.
, Sabino
, R. M.
, Pereira
, R. B. D.
, Popat
, K.
, Soares
, P.
, and Jackson
, M. J.
, 2021
, “Performance Investigation of Cryo-Treated End Mill on the Mechanical and In Vitro Behavior of Hybrid-Lubri-Coolant-Milled Ti-6Al-4V Alloy
,” J. Manuf. Processes
, 71
, pp. 472
–488
. 9.
Aliyu
, A. A.
, Abdul-Rani
, A. M.
, Ginta
, T. L.
, Prakash
, C.
, Axinte
, E.
, Razak
, M. A.
, and Ali
, S.
, 2017
, “A Review of Additive Mixed-Electric Discharge Machining: Current Status and Future Perspectives for Surface Modification of Biomedical Implants
,” Adv. Mater. Sci. Eng.
, 2017
, pp. 1
–23
. 10.
Talla
, G.
, Gangopadhayay
, S.
, and Biswas
, C. K.
, 2017
, “State of the Art in Powder-Mixed Electric Discharge Machining: A Review
,” Proc. Inst. Mech. Eng. Part B J. Eng. Manuf.
, 231
(14
), pp. 2511
–2526
. 11.
Joshi
, A. Y.
, and Joshi
, A. Y.
, 2019
, “A Systematic Review on Powder Mixed Electrical Discharge Machining
,” Heliyon
, 5
(12
), p. e02963
. 12.
Bui
, V. D.
, Mwangi
, J. W.
, and Schubert
, A.
, 2019
, “Powder Mixed Electrical Discharge Machining for Antibacterial Coating on Titanium Implant Surfaces
,” J. Manuf. Processes
, 44
, pp. 261
–270
. 13.
Kolli
, M.
, and Kumar
, A.
, 2014
, “Effect of Boron Carbide Powder Mixed Into Dielectric Fluid on Electrical Discharge Machining of Titanium Alloy
,” Procedia Mater. Sci.
, 5
, pp. 1957
–1965
. 14.
Kolli
, M.
, and Kumar
, A.
, 2017
, “Surfactant and Graphite Powder–Assisted Electrical Discharge Machining of Titanium Alloy
,” Proc. Inst. Mech. Eng. Part B J. Eng. Manuf.
, 231
(4
), pp. 641
–657
. 15.
Alam
, S. T.
, Amin
, A. N.
, Hossain
, M. I.
, Huq
, M.
, and Tamim
, S. H.
, 2021
, “Performance Evaluation of Graphite and Titanium Oxide Powder Mixed Dielectric for Electric Discharge Machining of Ti–6Al–4V
,” SN Appl. Sci.
, 3
(4
), pp. 1
–12
.16.
Yaşar
, H.
, and Ekmekci
, B.
, 2014
, “Ti-6Al-4V Surfaces in SiC Powder Mixed Electrical Discharge Machining
,” Adv. Mater. Res.
, 856
, pp. 226
–230
. 17.
Li
, L.
, Zhao
, L.
, Li
, Z. Y.
, Feng
, L.
, and Bai
, X.
, 2017
, “Surface Characteristics of Ti-6Al-4V by SiC Abrasive-Mixed EDM With Magnetic Stirring
,” Mater. Manuf. Processes
, 32
(1
), pp. 83
–86
. 18.
Öpöz
, T. T.
, Yaşar
, H.
, Ekmekci
, N.
, and Ekmekci
, B.
, 2018
, “Particle Migration and Surface Modification on Ti6Al4V in SiC Powder Mixed Electrical Discharge Machining
,” J. Manuf. Processes
, 31
, pp. 744
–758
. 19.
Joshi
, A. Y.
, and Joshi
, A. Y.
, 2021
, “Feasibility Analysis of Powder-Mixed Deionized Water as Dielectric for Machining Ti6Al4V
,” J. Inst. Eng. (India): C
, 102
(2
), pp. 337
–347
. 20.
Gosai
, N. D.
, and Joshi
, A. Y.
, 2016
, “Experimental Investigation and Optimization of Process Parameters Used in the Silicon Powder Mixed Electro Discharge Machining of Ti-6Al-4V Alloy Using Response Surface Methodology
,” J. Manuf. Sci. Prod.
, 16
(1
), pp. 21
–32
.21.
Shabgard
, M.
, and Khosrozadeh
, B.
, 2017
, “Investigation of Carbon Nanotube Added Dielectric on the Surface Characteristics and Machining Performance of Ti–6Al–4V Alloy in EDM Process
,” J. Manuf. Processes
, 25
, pp. 212
–219
. 22.
Kumar
, S. S.
, Varol
, T.
, Canakci
, A.
, Kumaran
, S. T.
, and Uthayakumar
, M.
, 2021
, “A Review on the Performance of the Materials by Surface Modification Through EDM
,” Int. J. Lightweight Mater. Manuf.
, 4
(1
), pp. 127
–144
.23.
Patel
, S.
, Thesiya
, D.
, and Rajurkar
, A.
, 2018
, “Aluminium Powder Mixed Rotary Electric Discharge Machining (PMEDM) on Inconel 718
,” Aust. J. Mech. Eng
, 16
(1
), pp. 21
–30
. 24.
Kumar
, A.
, Mandal
, A.
, Dixit
, A. R.
, and Das
, A. K.
, 2018
, “Performance Evaluation of Al2O3 Nano Powder Mixed Dielectric for Electric Discharge Machining of Inconel 825
,” Mater. Manuf. Processes
, 33
(9
), pp. 986
–995
. 25.
Peças
, P.
, and Henriques
, E.
, 2003
, “Influence of Silicon Powder-Mixed Dielectric on Conventional Electrical Discharge Machining
,” Int. J. Mach. Tools Manuf.
, 43
(14
), pp. 1465
–1471
. 26.
Ekmekci
, B.
, Yaşar
, H.
, and Ekmekci
, N.
, 2016
, “A Discharge Separation Model for Powder Mixed Electrical Discharge Machining
,” ASME J. Manuf. Sci. Eng.
, 138
(8
), p. 081006.27.
Fong
, T. Y.
, and Chen
, F. C.
, 2005
, “Investigation Into Some Surface Characteristics of Electrical Discharge Machined SKD-11 Using Powder-Suspension Dielectric Oil
,” J. Mater. Process. Technol.
, 170
(1–2
), pp. 385
–391
. 28.
Ekmekci
, N.
, and Ekmekci
, B.
, 2016
, “Electrical Discharge Machining of Ti6Al4V in Hydroxyapatite Powder Mixed Dielectric Liquid
,” Mater. Manuf. Processes
, 31
(13
), pp. 1663
–1670
. 29.
Ekmekci
, N.
, and Ekmekci
, B.
, 2014
, “Hydroxyapatite Deposition Onto Ti-6Al-4V Surface in Powder Mixed Electrical Discharge Machining
,” Adv. Mater. Res.
, 856
, pp. 205
–209
. 30.
Opoz
, T.
, Yasar
, H.
, Murphy
, M.
, Ekmekci
, N.
, and Ekmekci
, B.
, 2019
, “Ti6Al4V Surface Modification by Hydroxyapatite Powder Mixed Electrical Discharge Machining for Medical Application
,” Int. J. Adv. Eng. Pure Sci.
31.
Bui
, V. D.
, Mwangi
, J. W.
, Meinshausen
, A. K.
, Mueller
, A. J.
, Bertrand
, J.
, and Schubert
, A.
, 2020
, “Antibacterial Coating of Ti-6Al-4V Surfaces Using Silver Nano-Powder Mixed Electrical Discharge Machining
,” Surf. Coat. Technol.
, 383
.32.
Camara
, C.
, Peris-Lopez
, P.
, and Tapiador
, J. E.
, 2015
, “Security and Privacy Issues in Implantable Medical Devices: A Comprehensive Survey
,” J. Biomed. Inform.
, 55
, pp. 272
–289
. 33.
Packianather
, M. S.
, Le
, C. H.
, Pham
, D. T.
, and Le
, H. Q.
, 2018
, “Advanced Micro and Nano Manufacturing Technologies Used in Medical Domain
,” IFMBE Proc.
, 63
, pp. 637
–642
. 34.
Davis
, R.
, Singh
, A.
, Debnath
, K.
, Sabino
, R. M.
, Popat
, K.
, da Silva
, L. R. R.
, Soares
, P.
, and Machado
, Á. R.
, 2021
, “Surface Modification of Medical-Grade Ni55.6Ti44.4 Alloy via Enhanced Machining Characteristics of Zn Powder Mixed-μ-EDM
,” Surf. Coat. Technol.
, 425
, p. 127725
. 35.
Kibria
, G.
, Sarkar
, B. R.
, Pradhan
, B. B.
, and Bhattacharyya
, B.
, 2010
, “Comparative Study of Different Dielectrics for Micro-EDM Performance During Microhole Machining of Ti-6Al-4V Alloy
,” Int. J. Adv. Manuf. Technol.
, 48
(5–8
), pp. 557
–570
. 36.
Kibria
, G.
, and Bhattacharyya
, B.
, 2011
, “Investigation Into Micro-Hole Geometrical Accuracy During Micro-EDM of Ti-6Al-4V Employing Different Dielectrics
,” Int. J. Mach. Mach. Mater.
, 10
(4
), pp. 310
–325
.37.
Kuriachen
, B.
, and Mathew
, J.
, 2016
, “Effect of Powder Mixed Dielectric on Material Removal and Surface Modification in Microelectric Discharge Machining of Ti-6Al-4V
,” Mater. Manuf. Processes
, 31
(4
), pp. 439
–446
. 38.
Arun Pillai
, K. V.
, Hariharan
, P.
, and Krishna Murthy
, R.
, 2020
, “Micro ED Milling of Ti-6Al-4V with SiC Nano Powder Mixed Dielectrics at Different Ranges of Discharge Energy
,” Silicon
.39.
Tiwary
, A. P.
, Pradhan
, B. B.
, and Bhattacharyya
, B.
, 2019
, “Influence of Various Metal Powder Mixed Dielectric on Micro-EDM Characteristics of Ti-6Al-4V
,” Mater. Manuf. Processes
, 34
(10
), pp. 1103
–1119
. 40.
Liu
, C.
, Rashid
, A.
, Jahan
, M. P.
, and Ma
, J.
, 2019
, “Machining of High Aspect Ratio Micro-Holes on Titanium Alloy Using Silver Nano Powder Mixed Micro EDM Drilling
,” ASME 2019 International Mechanical Engineering Congress and Exposition
, 2A-2019, Salt Lake City, UT
, Nov. 11–14
.41.
Sharma
, D.
, Mohanty
, S.
, and Das
, A. K.
, 2020
, “Surface Modification of Titanium Alloy Using HBN Powder Mixed Dielectric Through Micro-Electric Discharge Machining
,” Surf. Coat. Technol.
, 381
, p. 125157
. 42.
Gomes
, C. C.
, Moreira
, L. M.
, Santos
, V. J. S. V.
, Ramos
, A. S.
, Lyon
, J. P.
, Soares
, C. P.
, and Santos
, F. V.
, 2011
, “Assessment of the Genetic Risks of a Metallic Alloy Used in Medical Implants
,” Genet. Mol. Biol.
, 34
(1
), pp. 116
–121
. 43.
Armillotta
, A.
, 2021
, “On the Role of Complexity in Machining Time Estimation
,” J. Intell. Manuf.
44.
Sagar
, P.
, Gupta
, P.
, and Kashyap
, I.
, 2021
, “A Forecasting Method with Efficient Selection of Variables in Multivariate Data Sets
,” Int. J. Inf. Technol.
45.
Bhaumik
, M.
, and Maity
, K.
, 2018
, “Effect of Different Tool Materials During EDM Performance of Titanium Grade 6 Alloy
,” Eng. Sci. Technol. Int. J.
, 21
(3
), pp. 507
–516
. 46.
Davis
, R.
, Singh
, A.
, Debnath
, K.
, Jackson
, M. J.
, Soares
, P.
, Amorim
, F. L.
, and Dutta
, H.
, 2021
, “Effect of Powder Particle Concentration and Tool Electrode Material Amid Zinc Powder-Mixed ΜEDM of Biocompatible Mg Alloy AZ91D
,” J. Mater. Eng. Perform.
47.
Mohanty
, S.
, Das
, A. K.
, and Dixit
, A. R.
, 2021
, “Influence of Tool Materials on Surface Modification Using ΜEDC Process
,” Surf. Eng.
, 37
(9
), pp. 1084
–1097
. 48.
Praveen
, L.
, Geeta Krishna
, P.
, Venugopal
, L.
, and Prasad
, N. E. C.
, 2018
, “Effects of Pulse on and off Time and Electrode Types on the Material Removal Rate and Tool Wear Rate of the Ti-6Al-4V Alloy Using EDM Machining With Reverse Polarity
,” IOP Conf. Ser.: Mater. Sci. Eng.
, 330
(1
), pp. 1
–8
.49.
Bhaumik
, M.
, and Maity
, K.
, 2019
, “Effect of Electrode Materials on Different EDM Aspects of Titanium Alloy
,” Silicon
, 11
(1
), pp. 187
–196
. 50.
Kaseem
, M.
, and Choe
, H. C.
, 2021
, “Simultaneous Improvement of Corrosion Resistance and Bioactivity of a Titanium Alloy via Wet and Dry Plasma Treatments
,” J. Alloys Compd.
, 851
, p. 156840
. 51.
Damiati
, L.
, Eales
, M. G.
, Nobbs
, A. H.
, Su
, B.
, Tsimbouri
, P. M.
, Salmeron-Sanchez
, M.
, and Dalby
, M. J.
, 2018
, “Impact of Surface Topography and Coating on Osteogenesis and Bacterial Attachment on Titanium Implants
,” J. Tissue Eng.
, 9
. 52.
Ellingsen
, J. E.
, Thomsen
, P.
, and Lyngstadaas
, S. P.
, 2006
, “Advances in Dental Implant Materials and Tissue Regeneration
,” Periodontol. 2000
, 41
(1
), pp. 136
–156
. 53.
Ramin
, B. B. S.
, Rufato
, K. B.
, Sabino
, R. M.
, Popat
, K. C.
, Kipper
, M. J.
, Martins
, A. F.
, and Muniz
, E. C.
, 2019
, “Chitosan/Iota-Carrageenan/Curcumin-Based Materials Performed by Precipitating Miscible Solutions Prepared in Ionic Liquid
,” J. Mol. Liq.
, 290
.54.
Manivasagam
, V. K.
, and Popat
, K. C.
, 2020
, “In Vitro Investigation of Hemocompatibility of Hydrothermally Treated Titanium and Titanium Alloy Surfaces
,” ACS Omega
, 5
(14
), pp. 8108
–8120
. 55.
Sabino
, R. M.
, Mondini
, G.
, Kipper
, M. J.
, Martins
, A. F.
, and Popat
, K. C.
, 2021
, “Tanfloc/Heparin Polyelectrolyte Multilayers Improve Osteogenic Differentiation of Adipose-Derived Stem Cells on Titania Nanotube Surfaces
,” Carbohydr. Polym.
, 251
, p. 117079
. 56.
Al-Amin
, M.
, Abdul Rani
, A. M.
, Abdu Aliyu
, A. A.
, Abdul Razak
, M. A.
, Hastuty
, S.
, and Bryant
, M. G.
, 2020
, “Powder Mixed-EDM for Potential Biomedical Applications: A Critical Review
,” Mater. Manuf. Processes
, 35
(16
), pp. 1789
–1811
. 57.
Prihandana
, G. S.
, Mahardika
, M.
, Hamdi
, M.
, Wong
, Y. S.
, Miki
, N.
, and Mitsui
, K.
, 2013
, “Study of Workpiece Vibration in Powder-Suspended Dielectric Fluid in Micro-EDM Processes
,” Int. J. Precis. Eng. Manuf.
, 14
(10
), pp. 1817
–1822
. 58.
Singh
, R.
, Singh
, R. P.
, and Trehan
, R.
, 2021
, “State of the Art in Processing of Shape Memory Alloys With Electrical Discharge Machining: A Review
,” Proc. Inst. Mech. Eng. Part B J. Eng. Manuf.
, 235
(3
), pp. 333
–366
. 59.
Mower
, T. M.
, 2014
, “Degradation of Titanium 6Al-4V Fatigue Strength Due to Electrical Discharge Machining
,” Int. J. Fatigue
, 64
, pp. 84
–96
. 60.
Peng
, P. W.
, Ou
, K. L.
, Lin
, H. C.
, Pan
, Y. N.
, and Wang
, C. H.
, 2010
, “Effect of Electrical-Discharging on Formation of Nanoporous Biocompatible Layer on Titanium
,” J. Alloys Compd.
, 492
(1–2
), pp. 625
–630
. 61.
Liu
, J.
, Liu
, J.
, Attarilar
, S.
, Wang
, C.
, Tamaddon
, M.
, Yang
, C.
, Xie
, K.
, Yao
, J.
, Wang
, L.
, Liu
, C.
, and Tang
, Y.
, 2020
, “Nano-Modified Titanium Implant Materials: A Way Toward Improved Antibacterial Properties
,” Front. Bioeng. Biotechnol.
, 8
. 62.
Gittens
, R. A.
, McLachlan
, T.
, Olivares-Navarrete
, R.
, Cai
, Y.
, Berner
, S.
, Tannenbaum
, R.
, Schwartz
, Z.
, Sandhage
, K. H.
, and Boyan
, B. D.
, 2011
, “The Effects of Combined Micron-/Submicron-Scale Surface Roughness and Nanoscale Features on Cell Proliferation and Differentiation
,” Biomaterials
, 32
(13
), pp. 3395
–3403
. 63.
Leichtweiss
, T.
, Henning
, R. A.
, Koettgen
, J.
, Schmidt
, R. M.
, Holländer
, B.
, Martin
, M.
, Wuttig
, M.
, and Janek
, J.
, 2014
, “Amorphous and Highly Nonstoichiometric Titania (TiOx) Thin Films Close to Metal-Like Conductivity
,” J. Mater. Chem. A
, 2
(18
), pp. 6631
–6640
. 64.
Trino
, L. D.
, Dias
, L. F. G.
, Albano
, L. G. S.
, Bronze-Uhle
, E. S.
, Rangel
, E. C.
, Graeff
, C. F. O.
, and Lisboa-Filho
, P. N.
, 2018
, “Zinc Oxide Surface Functionalization and Related Effects on Corrosion Resistance of Titanium Implants
,” Ceram. Int.
, 44
(4
), pp. 4000
–4008
. 65.
Tan
, L.
, Liu
, X.
, and Wu
, S.
, 2020
, “Construction of Bio-Functionalized ZnO Coatings on Titanium Implants With Both Self-Antibacterial and Osteoinductive Properties
,” Racing for the Surface
. 66.
Namavar
, F.
, Sabirianov
, R. F.
, Marton
, D.
, Rubinstein
, A.
, and Garvin
, K. L.
, 2005
, “Why Is Titanium Biocompatible?
,” Phys Chem Chem Phys.
, 11
(2
), pp. 6597
–6609
.67.
Miralami
, R.
, Koepsell
, L.
, Premaraj
, T.
, Kim
, B.
, Thiele
, G. M.
, Sharp
, J. G.
, Garvin
, K. L.
, and Namavar
, F.
, 2013
, “Comparing Biocompatibility of Nanocrystalline Titanium and Titanium-Oxide With Microcrystalline Titanium
,” Mater. Res. Soc. Symp. Proc.
, 1569
, pp. 91
–96
. 68.
Stewart
, C.
, Akhavan
, B.
, Wise
, S. G.
, and Bilek
, M. M. M.
, 2019
, “A Review of Biomimetic Surface Functionalization for Bone-Integrating Orthopedic Implants: Mechanisms, Current Approaches, and Future Directions
,” Prog. Mater. Sci.
, 106
, p. 100588
. 69.
Parisi
, L.
, Ghezzi
, B.
, Bianchi
, M. G.
, Toffoli
, A.
, Rossi
, F.
, Bussolati
, O.
, and Macaluso
, G. M.
, 2020
, “Titanium Dental Implants Hydrophilicity Promotes Preferential Serum Fibronectin Over Albumin Competitive Adsorption Modulating Early Cell Response
,” Mater. Sci. Eng. C
, 117
, p. 111307
. 70.
Bhosle
, S. M.
, and Friedrich
, C. R.
, 2017
, “Wetting Behavior and Chemistry of Titanium Nanotubular Orthopedic Surfaces: Effect of Aging and Thermal Annealing
,” J. Bio. Tribo.Corros.
, 3
(2
), p. 26
. 71.
Menzies
, K. L.
, and Jones
, L.
, 2010
, “The Impact of Contact Angle on the Biocompatibility of Biomaterials
,” Optom. Vis. Sci.
, 87
(6
), pp. 387
–399
. 72.
Rufato
, K. B.
, Souza
, P. R.
, de Oliveira
, A. C.
, Berton
, S. B. R.
, Sabino
, R. M.
, Muniz
, E. C.
, Popat
, K. C.
, Radovanovic
, E.
, Kipper
, M. J.
, and Martins
, A. F.
, 2021
, “Antimicrobial and Cytocompatible Chitosan, N,N,N-Trimethyl Chitosan, and Tanfloc-Based Polyelectrolyte Multilayers on Gellan Gum Films
,” Int. J. Biol. Macromol.
, 183
, pp. 727
–742
. 73.
Stepanovska
, J.
, Matejka
, R.
, Otahal
, M.
, Rosina
, J.
, and Bacakova
, L.
, 2020
, “The Effect of Various Surface Treatments of Ti6Al4V on the Growth and Osteogenic Differentiation of Adipose Tissue-Derived Stem Cells
,” Coatings
, 10
(8
), p. 762
. 74.
Sabino
, R. M.
, Rau
, J. V.
, De Bonis
, A.
, De Stefanis
, A.
, Curcio
, M.
, Teghil
, R.
, and Popat
, K. C.
, 2021
, “Manganese-Containing Bioactive Glass Enhances Osteogenic Activity of TiO2 Nanotube Arrays
,” Appl. Surf. Sci.
, 570
, p. 151163
. 75.
Attia
, G. H.
, Moemen
, Y. S.
, Youns
, M.
, Ibrahim
, A. M.
, Abdou
, R.
, and El Raey
, M. A.
, 2021
, “Antiviral Zinc Oxide Nanoparticles Mediated by Hesperidin and In Silico Comparison Study Between Antiviral Phenolics as Anti-SARS-CoV-2
,” Colloids Surf., B
, 203
, p. 111724
. 76.
Hamdi
, M.
, Abdel-Bar
, H. M.
, Elmowafy
, E.
, El-Khouly
, A.
, Mansour
, M.
, and Awad
, G. A. S.
, 2021
, “Investigating the Internalization and COVID-19 Antiviral Computational Analysis of Optimized Nanoscale Zinc Oxide
,” ACS Omega
, 6
(10
), pp. 6848
–6860
. 77.
El-Megharbel
, S. M.
, Alsawat
, M.
, Al-Salmi
, F. A.
, and Hamza
, R. Z.
, 2021
, “Utilizing of (Zinc Oxide Nano-Spray) for Disinfection Against ‘SARS-CoV-2’ and Testing Its Biological Effectiveness on Some Biochemical Parameters During (COVID-19 Pandemic)—ZnO Nanoparticles Have Antiviral Activity Against (SARS-CoV-2)
,” Coatings
, 11
(4
), p. 388
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