The design of multimaterial lattice structures with optimized elasticity tensor, coefficient of thermal expansion (CTE), and thermal conductivity is the main objective of the research presented in this article. In addition, the additive manufacturability of the lattice structure is addressed using a prismatic density filter to eliminate support structures, and an octant symmetry filter is used to design symmetric lattices. A density-based topology optimization model is formulated with a homogenization method and solved using a sequential linear programming method to obtain the desired unit cell geometry of the lattice structure. The optimized unit cell obtained has high mechanical stiffness, a low CTE, and low thermal conductivity. A finite element analysis is carried out on the optimized lattice structure and an equivalent cube of computed effective properties (with the same loading and boundary conditions) to validate the computed homogenized material properties. The results from the finite element analysis show that the methodology followed to generate the lattice structure is accurate. Such lattice structures with tailored material properties can be used in aerospace parts that are subjected to mechanical and thermal loads. The complex multimaterial geometry produced from the topology optimization routine presented here is intended explicitly for the manufacture of parts using the directed energy deposition process with multiple material deposition nozzles.