Bone has very different thermal and electrical properties with the surrounding tissues. Misjustification of the heating dosage during an electromagnetic (EM) hyperthermia may lead to the failure of the treatment. Here aiming to disclose such clinically important issue, the present study presented a theoretical evaluation on the heating effects of magnetic-nanoparticles (MNPs) enhanced hyperthermia on the liver tumor underneath the ribs with bone features particularly addressed. The results revealed the following factors: (1) The existence of bone structure, i.e., ribs has an inevitable effect on the distribution of EM field; specifically, due to its lower dielectric property, the bone structure served as a barrier to attenuate the transport of EM energy and conversion of heat into the tissues, especially the tumor in the deep body. (2) Applying higher dosage or larger size MNPs would significantly enhance the temperature elevation at the target tumor tissues and thereby guarantee the performance of the hyperthermia. (3) Further parametric studies indicated that a higher frequency EM field would result in a worse heating effect; while stronger EM field will evidently enhance the heating effects of the hyperthermia process. This study promoted the better understanding of the EM heating on the bone structured tissues, and the findings are expected to provide valuable reference for planning an accurate surgery in future clinical liver tumor EM ablation.
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September 2015
This article was originally published in
Journal of Heat Transfer
Research-Article
Thermal Electrical Property Effects of Bone Structure on the Magnetic-Nanoparticle Enhanced Hyperthermia Targeting Tumor Underneath the Ribs
Chao Jin,
Chao Jin
Department of Biomedical Engineering,
School of Medicine,
School of Medicine,
Tsinghua University
,Beijing 100084
, China
Search for other works by this author on:
Zhi-Zhu He,
Zhi-Zhu He
Beijing Key Laboratory of Cryo-Biomedical
Engineering and Key Laboratory of Cryogenics,
Technical Institute of Physics and Chemistry,
Engineering and Key Laboratory of Cryogenics,
Technical Institute of Physics and Chemistry,
Chinese Academy of Sciences
,Beijing 100190
, China
Search for other works by this author on:
Jing Liu
Jing Liu
1
Department of Biomedical Engineering,
School of Medicine,
School of Medicine,
Tsinghua University
,Beijing 100084
, China
Beijing Key Laboratory of Cryo-Biomedical
Engineering and Key Laboratory of Cryogenics,
Technical Institute of Physics and Chemistry,
e-mail: jliubme@tsinghua.edu.cn
Engineering and Key Laboratory of Cryogenics,
Technical Institute of Physics and Chemistry,
Chinese Academy of Sciences
,Beijing 100190
, China
e-mail: jliubme@tsinghua.edu.cn
1Corresponding author.
Search for other works by this author on:
Chao Jin
Department of Biomedical Engineering,
School of Medicine,
School of Medicine,
Tsinghua University
,Beijing 100084
, China
Zhi-Zhu He
Beijing Key Laboratory of Cryo-Biomedical
Engineering and Key Laboratory of Cryogenics,
Technical Institute of Physics and Chemistry,
Engineering and Key Laboratory of Cryogenics,
Technical Institute of Physics and Chemistry,
Chinese Academy of Sciences
,Beijing 100190
, China
Jing Liu
Department of Biomedical Engineering,
School of Medicine,
School of Medicine,
Tsinghua University
,Beijing 100084
, China
Beijing Key Laboratory of Cryo-Biomedical
Engineering and Key Laboratory of Cryogenics,
Technical Institute of Physics and Chemistry,
e-mail: jliubme@tsinghua.edu.cn
Engineering and Key Laboratory of Cryogenics,
Technical Institute of Physics and Chemistry,
Chinese Academy of Sciences
,Beijing 100190
, China
e-mail: jliubme@tsinghua.edu.cn
1Corresponding author.
Manuscript received February 5, 2014; final manuscript received August 21, 2014; published online May 14, 2015. Assoc. Editor: Yogesh Jaluria.
J. Heat Transfer. Sep 2015, 137(9): 091005 (8 pages)
Published Online: September 1, 2015
Article history
Received:
February 5, 2014
Revision Received:
August 21, 2014
Online:
May 14, 2015
Citation
Jin, C., He, Z., and Liu, J. (September 1, 2015). "Thermal Electrical Property Effects of Bone Structure on the Magnetic-Nanoparticle Enhanced Hyperthermia Targeting Tumor Underneath the Ribs." ASME. J. Heat Transfer. September 2015; 137(9): 091005. https://doi.org/10.1115/1.4030213
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