Accurate prediction of burst speed and critical location of a rotating disk is a great concern for turbomachinery designers and enables the reduction of test numbers required to show rotor integrity during turbo-engine certification. Existing burst methodologies mainly focused on axial disks with well-defined bore, web, and rim regions and mostly depended on correction factors that require previous test data of rotors with similar sizes and features. Furthermore, variation of radial and hoop stresses in a radial disk is less predictable than in axial disks due to the asymmetric nature of impellers, which results in uneven distribution of centrifugal and bending loads. This paper aims to explain the experimental and numerical effort dedicated to building an accurate burst methodology for impellers. Elastoplastic finite element analyses are performed by incorporating geometric and material nonlinearities. Analysis results allowed the prediction of failure locations and observation of redistribution of stresses due to material plasticity as rotor speed increases. An extensive test campaign is carried out to validate the numerical analysis. Critical strain criteria that correspond to the plastic strain of true ultimate tensile strength (UTS), are used to determine burst speeds before tests. Experimental results are compared with Robinson's average hoop stress criteria, Hallinan's criteria, and critical strain criteria to show the strong and weak sides of these methodologies for an impeller application. The numerical burst speeds and crack initiation locations associated with critical strain criteria are found to be in good agreement with the spin test results.