There are increasing interests in converting solid waste or lignocellulosic biomass into gaseous fuels and using reciprocating internal combustion engine to generate electricity. A widely used technique is gasification. Gasification is a process where the solid fuel and air are introduced to a partial oxidation environment, and generate combustible gaseous called synthesis gas or syngas. Converting solid waste into gaseous fuel can reduce landfill and create income for process owners. However, it can be very challenging to use syngas on a gaseous fueled spark ignited (SI) engine, such as a natural gas (NG) engine. NG engines are typically developed with pipeline quality natural gas (PQNG). NG engines can operate at lean burn spark ignited (LBSI), or stoichiometric with exhaust gas recirculation (EGR) spark ignited (SESI) conditions. This work discusses the LBSI engine condition. NG engines can perform very differently when fueled with nonstandard gaseous fuels such as syngas without appropriate tuning. It is necessary to evaluate engine performance in terms of combustion duration, relative knock propensity, and NOx emissions for such applications. Due to constraints in time and resources it is often not feasible to test such fuel blends in the laboratory. An analytical method is needed to predict engine performance in a timely manner. This study investigated the possibility of using syngas on an SI engine developed with PQNG. Engine performance was predicted using in house developed models and PQNG as the reference fuel. Laminar flame speed (LFS), adiabatic flame temperature (AFT), and auto-ignition interval (AI) are used to predict combustion duration, engine out NOx and engine knock propensity relative to NG at the target lambda values. Single cylinder research engine data obtained under lean burn conditions fueled with PQNG was selected as the baseline. LFS, AFT, and AI of syngas were computed at reference conditions. Lambda of operation was predicted for syngas to provide the same burn rate as NG at the reference lambda value for NG. Analysis shows that, using syngas at the selected lambda, the engine can have less engine out NOx emissions and less knock propensity relative to NG at the same speed and load. Modifications to fuel system components may be required to avoid engine derate.