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Keywords: drug delivery
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Journal Articles
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2023, 145(6): 061007.
Paper No: BIO-22-1147
Published Online: March 8, 2023
...] Dastoorian , F. , Pakzad , L. , Kozinski , J. , and Behzadfar , E. , 2022 , “ A CFD Investigation on the Aerosol Drug Delivery in the Mouth–Throat Airway Using a Pressurized Metered-Dose Inhaler Device ,” Processes , 10 ( 7 ), p. 1230 . 10.3390/pr10071230 [6] Iwanaga...
Journal Articles
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2022, 144(11): 111003.
Paper No: BIO-21-1376
Published Online: June 16, 2022
...Jason N. Mehta; Brianna E. Morales; Fang-Chi Hsu; John H. Rossmeisl; Christopher G. Rylander Convection-enhanced delivery (CED) has been extensively studied for drug delivery to the brain due to its inherent ability to bypass the blood-brain barrier. Unfortunately, CED has also been shown...
Journal Articles
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. April 2011, 133(4): 044502.
Published Online: February 18, 2011
... of in vivo tissues. Such FEMs will provide basic understanding of normal and pathological tissue responses and lead to optimization of local drug delivery strategies. We present a coupled porohyperelastic mass transport (PHEXPT) finite element approach developed using a commercially available ABAQUS finite...
Journal Articles
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. October 2010, 132(10): 101003.
Published Online: September 28, 2010
...R. A. Guha; N. H. Shear; M. Papini The impact and penetration of high speed particles with the human skin is of interest for targeted drug delivery by transdermal powder injection. However, it is often difficult to perform penetration experiments on dermal tissue using micron scale particles...
Journal Articles
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. July 2009, 131(7): 071007.
Published Online: July 16, 2009
... During Infusion Into Brain-Tissue ,” Microvasc. Res. 0026-2862 , 44 ( 2 ), pp. 143 – 165 . 10.1016/0026-2862(92)90077-3 Chen , Z. J. , Broaddus , W. C. , Viswanathan , R. R. , Raghavan , R. , and Gillies , G. T. , 2002 , “ Intraparenchymal Drug Delivery via Positive...
Journal Articles
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074513.
Published Online: June 29, 2009
... pump out cytotoxic drugs from the intracellular space. In this study, we tested a hypothesis that freezing and thawing (F/T) may enhance intracellular drug delivery to MDR cancer cells via F/T-induced denaturation of MDR-associated proteins and/or membrane permeabilization. After a human MDR cancer...
Journal Articles
Journal Articles
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. February 2008, 130(1): 011015.
Published Online: February 20, 2008
...Frank E. Fresconi; Ajay K. Prasad The adverse health effects of inhaled particulate matter from the environment depend on its dispersion, transport, and deposition in the human airways. Similarly, precise targeting of deposition sites by pulmonary drug delivery systems also relies on characterizing...
Journal Articles
Journal Articles
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. October 2007, 129(5): 722–732.
Published Online: February 18, 2007
... contours are used to depict the strength of the secondary flow 15 11 2006 18 02 2007 aerosols bifurcation convection fluid oscillations lung pneumodynamics toxicology respiratory airway bifurcation lung flow secondary velocity aerosol transport dispersion drug...