Understanding of in vivo brain biomechanical behavior is critical in the study of traumatic brain injury (TBI) mechanisms and prevention. Using tagged magnetic resonance imaging, we measured spatiotemporal brain deformations in 34 healthy human volunteers under mild angular accelerations of the head. Two-dimensional (2D) Lagrangian strains were examined throughout the brain in each subject. Strain metrics peaked shortly after contact with a padded stop, corresponding to the inertial response of the brain after head deceleration. Maximum shear strain of at least 3% was experienced at peak deformation by an area fraction (median±standard error) of 23.5±1.8% of cortical gray matter, 15.9±1.4% of white matter, and 4.0±1.5% of deep gray matter. Cortical gray matter strains were greater in the temporal cortex on the side of the initial contact with the padded stop and also in the contralateral temporal, frontal, and parietal cortex. These tissue-level deformations from a population of healthy volunteers provide the first in vivo measurements of full-volume brain deformation in response to known kinematics. Although strains differed in different tissue type and cortical lobes, no significant differences between male and female head accelerations or strain metrics were found. These cumulative results highlight important kinematic features of the brain's mechanical response and can be used to facilitate the evaluation of computational simulations of TBI.
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October 2018
Research-Article
Statistical Characterization of Human Brain Deformation During Mild Angular Acceleration Measured In Vivo by Tagged Magnetic Resonance Imaging
Deva D. Chan,
Deva D. Chan
Department of Biomedical Engineering,
Rensselaer Polytechnic Institute,
Troy, NY 12180
Rensselaer Polytechnic Institute,
Troy, NY 12180
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Andrew K. Knutsen,
Andrew K. Knutsen
Center for Neuroscience and
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
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Yuan-Chiao Lu,
Yuan-Chiao Lu
Center for Neuroscience and
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
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Sarah H. Yang,
Sarah H. Yang
Center for Neuroscience and
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
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Elizabeth Magrath,
Elizabeth Magrath
Center for Neuroscience and
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
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Wen-Tung Wang,
Wen-Tung Wang
Center for Neuroscience and
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
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Philip V. Bayly,
Philip V. Bayly
Professor
Department of Mechanical Engineering
and Materials Science,
Washington University at St. Louis,
St. Louis, MO 63130
Department of Mechanical Engineering
and Materials Science,
Washington University at St. Louis,
St. Louis, MO 63130
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John A. Butman,
John A. Butman
Radiology and Imaging Sciences,
National Institutes of Health Clinical Center,
Bethesda, MD 20892
National Institutes of Health Clinical Center,
Bethesda, MD 20892
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Dzung L. Pham
Dzung L. Pham
Center for Neuroscience and
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892-1182
e-mail: dzung.pham@nih.gov
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
10 Center Drive, MSC 1182
,Bethesda, MD 20892-1182
e-mail: dzung.pham@nih.gov
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Deva D. Chan
Department of Biomedical Engineering,
Rensselaer Polytechnic Institute,
Troy, NY 12180
Rensselaer Polytechnic Institute,
Troy, NY 12180
Andrew K. Knutsen
Center for Neuroscience and
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Yuan-Chiao Lu
Center for Neuroscience and
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Sarah H. Yang
Center for Neuroscience and
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Elizabeth Magrath
Center for Neuroscience and
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Wen-Tung Wang
Center for Neuroscience and
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892
Philip V. Bayly
Professor
Department of Mechanical Engineering
and Materials Science,
Washington University at St. Louis,
St. Louis, MO 63130
Department of Mechanical Engineering
and Materials Science,
Washington University at St. Louis,
St. Louis, MO 63130
John A. Butman
Radiology and Imaging Sciences,
National Institutes of Health Clinical Center,
Bethesda, MD 20892
National Institutes of Health Clinical Center,
Bethesda, MD 20892
Dzung L. Pham
Center for Neuroscience and
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
Bethesda, MD 20892-1182
e-mail: dzung.pham@nih.gov
Regenerative Medicine,
The Henry M. Jackson Foundation for the
Advancement of Military Medicine,
10 Center Drive, MSC 1182
,Bethesda, MD 20892-1182
e-mail: dzung.pham@nih.gov
1Corresponding author.
Manuscript received September 19, 2017; final manuscript received February 19, 2018; published online June 21, 2018. Assoc. Editor: Barclay Morrison.
J Biomech Eng. Oct 2018, 140(10): 101005 (13 pages)
Published Online: June 21, 2018
Article history
Received:
September 19, 2017
Revised:
February 19, 2018
Citation
Chan, D. D., Knutsen, A. K., Lu, Y., Yang, S. H., Magrath, E., Wang, W., Bayly, P. V., Butman, J. A., and Pham, D. L. (June 21, 2018). "Statistical Characterization of Human Brain Deformation During Mild Angular Acceleration Measured In Vivo by Tagged Magnetic Resonance Imaging." ASME. J Biomech Eng. October 2018; 140(10): 101005. https://doi.org/10.1115/1.4040230
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