In traumatic brain injury (TBI), membranes such as the dura mater, arachnoid mater, and pia mater play a vital role in transmitting motion from the skull to brain tissue. Magnetic resonance elastography (MRE) is an imaging technique developed for noninvasive estimation of soft tissue material parameters. In MRE, dynamic deformation of brain tissue is induced by skull vibrations during magnetic resonance imaging (MRI); however, skull motion and its mode of transmission to the brain remain largely uncharacterized. In this study, displacements of points in the skull, reconstructed using data from an array of MRI-safe accelerometers, were compared to displacements of neighboring material points in brain tissue, estimated from MRE measurements. Comparison of the relative amplitudes, directions, and temporal phases of harmonic motion in the skulls and brains of six human subjects shows that the skull–brain interface significantly attenuates and delays transmission of motion from skull to brain. In contrast, in a cylindrical gelatin “phantom,” displacements of the rigid case (reconstructed from accelerometer data) were transmitted to the gelatin inside (estimated from MRE data) with little attenuation or phase lag. This quantitative characterization of the skull–brain interface will be valuable in the parameterization and validation of computer models of TBI.
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The Relationship of Three-Dimensional Human Skull Motion to Brain Tissue Deformation in Magnetic Resonance Elastography Studies
Andrew A. Badachhape,
Andrew A. Badachhape
Biomedical Engineering,
Washington University in St. Louis,
St. Louis, MO 63105
e-mail: abadachhape@wustl.edu
Washington University in St. Louis,
St. Louis, MO 63105
e-mail: abadachhape@wustl.edu
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Ruth J. Okamoto,
Ruth J. Okamoto
Mechanical Engineering and Materials Science,
Washington University in St. Louis,
St. Louis, MO 63105
Washington University in St. Louis,
St. Louis, MO 63105
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Ramona S. Durham,
Ramona S. Durham
Biomedical Engineering,
Washington University in St. Louis,
St. Louis, MO 63105
Washington University in St. Louis,
St. Louis, MO 63105
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Brent D. Efron,
Brent D. Efron
Mechanical Engineering and Materials Science,
Washington University in St. Louis,
St. Louis, MO 63105
Washington University in St. Louis,
St. Louis, MO 63105
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Sam J. Nadell,
Sam J. Nadell
Mechanical Engineering and Materials Science,
Washington University in St. Louis,
St. Louis, MO 63105
Washington University in St. Louis,
St. Louis, MO 63105
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Curtis L. Johnson,
Curtis L. Johnson
Biomedical Engineering,
University of Delaware,
Newark, DE 19716
University of Delaware,
Newark, DE 19716
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Philip V. Bayly
Philip V. Bayly
Biomedical Engineering,
Washington University in St. Louis,
St. Louis, MO 63105;
Washington University in St. Louis,
St. Louis, MO 63105;
Mechanical Engineering and Materials Science,
Washington University in St. Louis,
St. Louis, MO 63105
Washington University in St. Louis,
St. Louis, MO 63105
Search for other works by this author on:
Andrew A. Badachhape
Biomedical Engineering,
Washington University in St. Louis,
St. Louis, MO 63105
e-mail: abadachhape@wustl.edu
Washington University in St. Louis,
St. Louis, MO 63105
e-mail: abadachhape@wustl.edu
Ruth J. Okamoto
Mechanical Engineering and Materials Science,
Washington University in St. Louis,
St. Louis, MO 63105
Washington University in St. Louis,
St. Louis, MO 63105
Ramona S. Durham
Biomedical Engineering,
Washington University in St. Louis,
St. Louis, MO 63105
Washington University in St. Louis,
St. Louis, MO 63105
Brent D. Efron
Mechanical Engineering and Materials Science,
Washington University in St. Louis,
St. Louis, MO 63105
Washington University in St. Louis,
St. Louis, MO 63105
Sam J. Nadell
Mechanical Engineering and Materials Science,
Washington University in St. Louis,
St. Louis, MO 63105
Washington University in St. Louis,
St. Louis, MO 63105
Curtis L. Johnson
Biomedical Engineering,
University of Delaware,
Newark, DE 19716
University of Delaware,
Newark, DE 19716
Philip V. Bayly
Biomedical Engineering,
Washington University in St. Louis,
St. Louis, MO 63105;
Washington University in St. Louis,
St. Louis, MO 63105;
Mechanical Engineering and Materials Science,
Washington University in St. Louis,
St. Louis, MO 63105
Washington University in St. Louis,
St. Louis, MO 63105
1Corresponding author.
Manuscript received September 1, 2016; final manuscript received February 15, 2017; published online March 21, 2017. Assoc. Editor: Barclay Morrison.
J Biomech Eng. May 2017, 139(5): 051002 (12 pages)
Published Online: March 21, 2017
Article history
Received:
September 1, 2016
Revised:
February 15, 2017
Connected Content
A companion article has been published:
Erratum: “The Relationship of Three-Dimensional Human Skull Motion to Brain Tissue Deformation in Magnetic Resonance Elastography Studies” (ASME J. Biomech. Eng., 2017, 139(5), p. 051002; DOI: 10.1115/1.4036146) to Paper Number BIO-16-1363
Citation
Badachhape, A. A., Okamoto, R. J., Durham, R. S., Efron, B. D., Nadell, S. J., Johnson, C. L., and Bayly, P. V. (March 21, 2017). "The Relationship of Three-Dimensional Human Skull Motion to Brain Tissue Deformation in Magnetic Resonance Elastography Studies." ASME. J Biomech Eng. May 2017; 139(5): 051002. https://doi.org/10.1115/1.4036146
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