The notion that both adaptive and maladaptive cardiac remodeling occurs in response to mechanical loading has informed recent progress in cardiac tissue engineering. Today, human cardiac tissues engineered in vitro offer complementary knowledge to that currently provided by animal models, with profound implications to personalized medicine. We review here recent advances in the understanding of the roles of mechanical signals in normal and pathological cardiac function, and their application in clinical translation of tissue engineering strategies to regenerative medicine and in vitro study of disease.
Tissue-Engineering for the Study of Cardiac Biomechanics
Manuscript received November 11, 2015; final manuscript received December 15, 2015; published online January 27, 2016. Editor: Victor H. Barocas.
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Ma, S. P., and Vunjak-Novakovic, G. (January 27, 2016). "Tissue-Engineering for the Study of Cardiac Biomechanics." ASME. J Biomech Eng. February 2016; 138(2): 021010. https://doi.org/10.1115/1.4032355
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