In the present study, a 1-D dynamic permeation of a monovalent electrolyte solution through a negatively charged-hydrated cartilaginous tissue is analyzed using the mechano-electrochemical theory developed by Lai et al. (1991) as the constitutive model for the tissue. The spatial distributions of stress, strain, fluid pressure, ion concentrations, electrical potential, ion and fluid fluxes within and across the tissue have been calculated. The dependencies of these mechanical, electrical and physicochemical responses on the tissue fixed charge density, with specified modulus, permeability, diffusion coefficients, and frequency and magnitude of pressure differential are determined. The results demonstrate that these mechanical, electrical and physicochemical fields within the tissue are intrinsically and nonlinearly coupled, and they all vary with time and depth within the tissue.
Analysis of the Dynamic Permeation Experiment with Implication to Cartilaginous Tissue Engineering
Professor Emeritus of Mechanical Engineering and Orthopaedic Bioengineering,
Stanley Dicker Professor of Biomedical Engineering and Orthopaedic Bioengineering,
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division March 17, 2003; revision received December 31, 2003. Associate Editor: J. S. Waynee.
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Gu, W. Y., Sun, D. N., Lai, W. M., and Mow, V. C. (September 27, 2004). "Analysis of the Dynamic Permeation Experiment with Implication to Cartilaginous Tissue Engineering ." ASME. J Biomech Eng. August 2004; 126(4): 485–491. https://doi.org/10.1115/1.1785806
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