In human voice production (phonation), linear small-amplitude vocal fold oscillation occurs only under restricted conditions. Physiologically, phonation more often involves large-amplitude oscillation associated with tissue stresses and strains beyond their linear viscoelastic limits, particularly in the lamina propria extracellular matrix (ECM). This study reports some preliminary measurements of tissue deformation and failure response of the vocal fold ECM under large-strain shear. The primary goal was to formulate and test a novel constitutive model for vocal fold tissue failure, based on a standard-linear cohesive-zone (SL-CZ) approach. Tissue specimens of the sheep vocal fold mucosa were subjected to torsional deformation in vitro, at constant strain rates corresponding to twist rates of 0.01, 0.1, and 1.0 rad/s. The vocal fold ECM demonstrated nonlinear stress-strain and rate-dependent failure response with a failure strain as low as 0.40 rad. A finite-element implementation of the SL-CZ model was capable of capturing the rate dependence in these preliminary data, demonstrating the model’s potential for describing tissue failure. Further studies with additional tissue specimens and model improvements are needed to better understand vocal fold tissue failure.
Skip Nav Destination
Article navigation
August 2004
Technical Papers
Vocal Fold Tissue Failure: Preliminary Data and Constitutive Modeling†
Roger W. Chan
Roger W. Chan
Department of Otolaryngology-Head and Neck Surgery, Graduate Program in Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, TX 75390
Thomas Siegmund School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907
Search for other works by this author on:
Roger W. Chan
Department of Otolaryngology-Head and Neck Surgery, Graduate Program in Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, TX 75390
Thomas Siegmund School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division February 3, 2003; revision received January 22, 2004. Associate Editor: P. V. Bayly.
J Biomech Eng. Aug 2004, 126(4): 466-474 (9 pages)
Published Online: September 27, 2004
Article history
Received:
February 3, 2003
Revised:
January 22, 2004
Online:
September 27, 2004
Citation
Chan, R. W. (September 27, 2004). "Vocal Fold Tissue Failure: Preliminary Data and Constitutive Modeling." ASME. J Biomech Eng. August 2004; 126(4): 466–474. https://doi.org/10.1115/1.1785804
Download citation file:
Get Email Alerts
Effect of Internal Mechanical Environment of Porous Scaffolds on Mechano-driven Bone Ingrowth: A Numerical Study
J Biomech Eng (September 2023)
In Silico Mechanical Effort Analysis of the All-On-4 Design Performed With Platform-Switching Distal Short Dental Implants
J Biomech Eng (September 2023)
Related Articles
Effects of Anterior Shear Displacement Rate on the Structural Properties of the Porcine Cervical Spine
J Biomech Eng (September,2010)
The Role of Flow-Independent Viscoelasticity in the Biphasic Tensile and Compressive Responses of Articular Cartilage
J Biomech Eng (October,2001)
A Continuous Method to Compute Model Parameters for Soft Biological Materials
J Biomech Eng (July,2011)
Related Proceedings Papers
Related Chapters
Characterization of Tissue Viscoelasticity from Shear Wave Speed Dispersion
Biomedical Applications of Vibration and Acoustics in Imaging and Characterizations
Flexibility Analysis
Process Piping: The Complete Guide to ASME B31.3, Third Edition
Introduction and Definitions
Handbook on Stiffness & Damping in Mechanical Design