The propagation of transient elastic waves in a three-dimensional multilayered medium subjected to general dynamic loadings is analyzed in this study. One of the objectives of this study is to develop an effective analytical method for determining transient full-field solutions in the multilayered medium subjected to nonaxisymmetric dynamic loadings. The wave field is decomposed into two parts; one is the system of waves and the other is the system, each of which propagates independently in a horizontally layered medium. A simple relationship between solutions of two- and three-dimensional problems in the Fourier transform domain is also presented. A matrix solution in the triple transform domain is obtained by Brownwich expansion and the inverse transform is inverted by Cagniard’s method. The matrix representation of the solution can be easily used to calculate the transient response of the multilayered medium without tracing the ray path manually. The formulas presented in this study enable us to calculate the long-time transient responses of the multilayered medium for three-dimensional configuration. The theoretical transient solution for a layer overlaying a half-space subjected to an arbitrarily oriented point force is presented in detail. The numerical calculations are compared with experimental measurements for the surface displacement response on a plate and a layer overlaying a half-space subjected to an axisymmetric point force. The numerical investigation is also carried out for nonaxisymmetric loading problem of a layer overlaying a half-space.