In past decades, it has been well demonstrated that cellular contractile forces against the extracellular matrix (ECM) plays an important role in regulating cellular behaviors such as spreading, adhesion and differentiation . Recent studies have found that focal adhesions (FAs) and subcellular contractile forces mediated by FAs have an intimate connection and form an important feedback loop to control cellular mechanotransduction in response to mechanical cues such as matrix rigidity, cell geometry and external forces . Therefore, understanding how FA-mediated contractile forces are regulated by those factors is critical for our understanding of cellular mechanotransduction and mechano-responsiveness.
- Bioengineering Division
Cell Shape Dictates Differential Sensitivity of Subcellular Contractile Forces in Response to Directional Substrate Stretch
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Shao, Y, Mann, JM, & Fu, J. "Cell Shape Dictates Differential Sensitivity of Subcellular Contractile Forces in Response to Directional Substrate Stretch." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT35A001. ASME. https://doi.org/10.1115/SBC2013-14225
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