Chondrocytes play a critical role in cartilage remodeling by mediating the biosynthesis, organization, and modification of extracellular matrix (ECM) . Previous studies showed that chondrocytes are highly sensitive to the surrounding mechanical and osmotic environments . However, how these signals are perceived and transduced by chondrocytes remains unclear. One of the earliest responses of chondrocytes to stimuli is a transient oscillation in intracellular Ca2+ concentration ([Ca2+]i) . The major objective of this study was to investigate and compare the Ca2+ signaling of chondrocytes, including both primary cells and chondrogenic cell line, under mechanical stimulus  and osmotic stress. The roles of seven essential pathways in Ca2+ signaling were further examined using pharmacological inhibitors.
- Bioengineering Division
Calcium Signaling of Chondrocytes Under Osmotic Stress and Mechanical Stimulation
- Views Icon Views
- Share Icon Share
- Search Site
Li, W, Park, M, Kirn-Safran, C, Wang, L, & Lu, XL. "Calcium Signaling of Chondrocytes Under Osmotic Stress and Mechanical Stimulation." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 329-330. ASME. https://doi.org/10.1115/SBC2012-80811
Download citation file: