In vivo  and in vitro [2–4] studies show that cell and matrix alignment can be significantly affected by mechanical stimuli. Even in highly aligned engineered tissues, cells are able to remodel the collagen orientation when loading conditions are altered .
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The Transient Response of a Collagen Remodeling Theory Based on Strain-Dependent Collagen Degradation
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Cilingir, A, Wilson, W, Ito, K, & van Donkelaar, CC. "The Transient Response of a Collagen Remodeling Theory Based on Strain-Dependent Collagen Degradation." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 215-216. ASME. https://doi.org/10.1115/SBC2012-80594
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