Heart disease causes about 15% of deaths in the United States; about two thirds of these cases are due to coronary artery disease . Post myocardial infarction (MI), left ventricular (LV) remodeling ensues and leads to geometric changes that result in dilation and thinning of the myocardial wall. This increases stress in the infarct and healthy tissue and ultimately results in heart failure. Injectable bulking agents have recently emerged as a promising therapy to address these maladaptive changes. As suggested by the Law of Laplace, thickening of the myocardium should decrease stress on the heart and potentially attenuate the negative effects of LV remodeling .
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Tunable Hyaluronic Acid Hydrogels to Alter and Understand Left Ventricular Remodeling
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Tous, E, Ifkovits, JL, Dorsey, SM, Szczesny, SE, Koomalsingh, KJ, Shuto, T, Soeda, T, Gorman, JH, III, Elliott, DM, Gorman, RC, & Burdick, JA. "Tunable Hyaluronic Acid Hydrogels to Alter and Understand Left Ventricular Remodeling." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 1013-1014. ASME. https://doi.org/10.1115/SBC2012-80284
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