Many studies have investigated effects of drug administration and gene transfer to treat tumors in small animal models. Microcirculation plays important roles in the development and growth of tissues; a tumor proliferates by angiogenesis [1], resulting in the formation of a dense microvasculature, while the microvasculature degenerates in locations where necrosis or apoptosis occurs. Hence, the growth of a tumor can be evaluated based on comprehension of the morphology of microcirculation. Enhanced visualizations of small blood vessels enabled by microbubbles or contrast agent have been reported. The maximum intensity persistence (MIP) method, which maintains the maximum brightness when the contrast agent passes through the vessel, is a representative visualization method already incorporated in existing ultrasonic equipment. However, the performance of the MIP method is deteriorated by changes of brightness due to in vivo movement accompanying heartbeat and breathing. Therefore, complicated processes are necessary to eliminate the effects of such movement by monitoring heartbeat with an echocardiogram (ECG) and by detecting breathing with a pressure sensor.
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Visualization of Microcirculation Based on Brightness Variation in Contrast-Enhanced Ultrasound
Kenichi Funamoto,
Kenichi Funamoto
Tohoku University, Sendai, Japan
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Toshiyuki Hayase,
Toshiyuki Hayase
Tohoku University, Sendai, Japan
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Tetsuya Kodama
Tetsuya Kodama
Tohoku University, Sendai, Japan
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Kenichi Funamoto
Tohoku University, Sendai, Japan
Toshiyuki Hayase
Tohoku University, Sendai, Japan
Tetsuya Kodama
Tohoku University, Sendai, Japan
Paper No:
SBC2010-19349, pp. 219-220; 2 pages
Published Online:
July 15, 2013
Citation
Funamoto, K, Hayase, T, & Kodama, T. "Visualization of Microcirculation Based on Brightness Variation in Contrast-Enhanced Ultrasound." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 219-220. ASME. https://doi.org/10.1115/SBC2010-19349
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