Glaucoma is a chronic and progressive optic neuropathy that gradually narrows the field of vision and can culminate in blindness. Despite extensive and prolonged research efforts, the mechanisms that initiate and fuel progression of the disease are not well understood. However, reduction of intraocular pressure (IOP) has been shown to be an effective therapy for slowing glaucomatous progression, although the specific role of IOP in the disease is not well understood.

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