Arterial restenosis associated with intimal hyperplasia at stent revascularization sites remains the major cause of long-term failure. The objective of this study was to determine the effect of flow in promoting endothelial cell migration and the effect of re-endothelialization on smooth muscle cell (SMC) proliferation. This study demonstrated that re-endothelialization reduces SMC proliferation and migration and provides model systems to study approaches to increasing endothelial healing.
- Bioengineering Division
Flow Increases Endothelial Migration and Inhibits Smooth Muscle Cell Proliferation in Artery and Co-Culture Models
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Lee, Y, Luo, J, Sprague, E, & Han, H. "Flow Increases Endothelial Migration and Inhibits Smooth Muscle Cell Proliferation in Artery and Co-Culture Models." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 305-306. ASME. https://doi.org/10.1115/SBC2008-192475
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