Today’s globalized manufacturing enterprise necessitates a new imperative for the academe to generate internationally astute engineers to enable manufacturing companies to collaborate in a global market in the 21st century. This paper presents author’s perspectives on manufacturing engineering education system in a changing world. First, issues, challenges, and strategies are discussed. Second, various industry/university cooperative research models in the US, Japan, Germany, and Taiwan are examined. Finally, challenges in education system and research collaboration in moving the innovation to a global marketplace is addressed.