Abstract
Cultured chondrocytes exhibit cathodal migration when subjected to applied direct current (DC) electric fields [1]. Our studies showed a 2-fold enhancement in migratory velocity at physiologic temperature (∼37°C) compared to room temperature (∼25°C). The inositol phosphate pathway antagonists, U-73122 and neomycin, were found to inhibit the directed response, indicating that it may be involved in chondrocyte migration. Further understanding of the molecular mechanisms underlying chondrocyte migration and galvanotaxis may contribute to the development of new strategies for cartilage repair.
Volume Subject Area:
Tissue Engineering Symposium
This content is only available via PDF.
Copyright © 2000 by ASME
You do not currently have access to this content.
