Thermoplastics have been increasingly employed for microfluidic devices due to their manufacturability, low cost, and biocompatibility. A microfluidic device consists of a number of necessary building blocks, including microvalves that are often used for flow regulation. The state-of-the-art of the microfluidic valve technology is polydimethylsiloxane (PDMS)-based elastic membrane valve. This paper is to report the integration of the elastomer valve into a thermoplastic device. The valves were designed for a two-dimensional protein separation device, which was fabricated from cyclic olefin copolymers (COC). To realize the goal of integrating the elastomer-based valves in the device, the key challenge is to achieve strong bonding between COC and PDMS so that the device will not delaminate when a pressure is built up after the valves are closed. Microvalve arrays were fabricated in a COC/PDMS/COC device to facilitate the introduction of two types of separation media, without cross-contamination, into orthogonal channels in order to achieve two-dimensional separation. In addition, we studied thermal actuation in the microvalve, as an alternative to pneumatic actuation in the conventional PDMS-based elastomer valve. The thermally actuated valves can be self-contained, requiring less-bulky external accessories than pneumatically actuated valves.
- Heat Transfer Division
- Fluids Engineering Division
Microfluidic Valve Arrays in Thermoplastic Devices
Fan, ZH, Gu, P, Augustine, S, Liu, K, Freitag, H, & Nishida, T. "Microfluidic Valve Arrays in Thermoplastic Devices." Proceedings of the ASME 2012 10th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2012 Heat Transfer Summer Conference and the ASME 2012 Fluids Engineering Division Summer Meeting. ASME 2012 10th International Conference on Nanochannels, Microchannels, and Minichannels. Rio Grande, Puerto Rico, USA. July 8–12, 2012. pp. 453-458. ASME. https://doi.org/10.1115/ICNMM2012-73021
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