The StreamVane™ swirl distortion generator, developed by Virginia Tech, can efficiently reproduce the boundary layer of an airframe or duct found in boundary layer ingesting (BLI) aircraft. Due to manufacturing limitations, the vanes within StreamVanes induce unsteady, vortical wakes, commonly known as a von Karman vortex street. This paper investigates the use of a commercial URANS code and SST turbulence model to predict the vortex shedding frequency from the vanes. The objective was accomplished in two main tasks. First, the CFD methodology was validated by modeling the fluid dynamics of a linear cascade experiment done by the von Karman Institute. Second, the same methodology was applied to airfoils used in StreamVane design to calculate the shedding frequency as a function of turning angle and TE thickness. It was predicted that an increase in turning angle exponentially increased the shedding frequency while an increase in TE thickness exponentially decreased the shedding frequency. The results provided a correlation between the shedding frequency and airfoil characteristics in StreamVanes as well as various turbomachinery components.