Microscale numerical modeling is currently the main tool used in wind industry to assess local wind resources. This paper presents a systematic procedure to adjust computational fluid dynamics (CFD) predicted wind profiles to experimental measurements in order to minimize their differences. It can be applied when wind measurements are available. Data from ten masts with several measurement heights from the well-known Bolund hill experiment provided the observed wind profiles. Simulated profiles were calculated with windsim CFD model for the aforementioned site. Speed-up correction factors were defined through the least squares method to cross-correlate each mast as reference to all the others inside the Bolund hill domain. After, the observed and the adjusted wind profiles at the same position were compared. Moreover, root mean square errors (RMSEs) were used as a metric to evaluate the estimations and the ability of each position to be predicted and predictor. Results have shown that the quality of the adjustment process depends on the flow characteristics at each position related to the incoming wind direction. Most affected positions, i.e., when the airflow overcomes the Bolund hill escarpment, present the less accurate wind profile estimations. The reference mast should be installed upstream of the potential wind turbines' locations and after the main local characteristics of topographical changes.